CFI dcast

CFI dcast: Damage-free Genome Editing — What’s Next in CRISPR

Jorge Conde, Andy Tran, and Hanne Winarsky

Posted June 26, 2019

Two recent scientific journal papers show what’s possible when CRISPR moves from cutting DNA tool to a full-fledged platform — expanding its toolkit for medicine across R&D, therapeutics, and diagnostics:

What do these two papers — both about techniques for getting rid of the need to cut the genome to edit it — make possible going forward, given the ongoing shift of biology becoming more like engineering? Where are we in the wave of the genome engineering “developer community” building on top of CRISPR with a constantly growing suite of programmable functionalities? CFI bio general partner Jorge Conde and bio deal team partner Andy Tran chat with Hanne Tidnam about these trends — and these two papers — in this short internal hallway-style conversation, part of our new CFI Journal Club series.

This podcast is also part of our new CFI bio newsletter, which you can sign up for at a16z.com/subscribe